1,2,3,5
Rationale 1: For the client to inherit an autosomal recessive disorder, his mother must have the disorder or be a carrier for it.
Rationale 2: Each sibling has a 50% chance of being a carrier and a 25% chance of developing the disease.
Rationale 3: For the client to inherit an autosomal recessive disorder, his father must have the disorder or be a carrier for it.
Rationale 4: The client's children have a 50% chance of being affected.
Rationale 5: As this client has manifested the disorder, it is clear he inherited two recessive genes. The father must contribute one gene to each child, so it must be a recessive gene, making the children carriers. If the children's mother also has the disorder or is a carrier, the children's chances of developing the disorder are higher.